N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide

Product Name: N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
CAS No.: 932986-18-0
Chemical Name: N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide
Synonyms: CS-1554;Azoramide;Azoraminde;N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide;N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide;Butanamide, N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-;N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
CBNumber: CB32641660
Molecular Formula: C15H17ClN2OS
Formula Weight: 308.83
MOL File: 932986-18-0.mol

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N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Property

Melting point:: 90-93°C
Density: 1.215
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml) or in ethanol (up to at least 25 mg/ml)
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18045
Product name: Azoramide
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18045
Product name: Azoramide
Purity: ≥98%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 18045
Product name: Azoramide
Purity: ≥98%
Packaging: 25mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 18045
Product name: Azoramide
Purity: ≥98%
Packaging: 50mg
Price: $341
Updated: 2024/03/01

TRC

Product number: A965090
Product name: Azoramide
Packaging: 25mg
Price: $75
Updated: 2021/12/16

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N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Chemical Properties,Usage,Production

Description

The unfolded protein response (UPR) maintains balance between protein synthesis and endoplasmic reticulum (ER) protein-folding by inhibiting translation to decrease global protein synthesis, increasing degradation and disposal of unfolded protein intermediates from the ER, and increasing the folding capacity of the ER by expanding its volume and increasing chaperone synthesis. Chronic ER stress leads to a defective UPR and is strongly associated with neurodegenerative diseases, cancers, and metabolic syndrome. Azoramide is a small molecule that has been shown to improve ER protein-folding ability by dose-dependently (1-25 μM) activating reporter genes whose expression is driven by the cellular UPR response element and the ER stress response element. At 1-25 μM, this compound can also stimulate the expression of multiple chaperone proteins to enhance ER chaperone capacity and induce phosphorylation of eukaryotic translation initiation factor 2α subunit (eIF2α) to reduce protein synthesis. At 150 mg/kg, azoramide exerts antidiabetic activity in both ob/ob and diet-induced obese mice, improving insulin sensitivity and glucose homeostasis, as well as protecting pancreatic β cells against ER stress.

Uses

Azoramide improves endoplasmic reticulum (ER) protein-folding ability and activates ER chaperone capacity to protect cells against ER stress in multiple systems. It also showed antidiabetic activity by improving insulin sensitivity and pancreatic β cell function.

References

1) Fu?(2015), Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity; Sci. Transl. Med., 7?292ra98

N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide Suppliers

China 83 India 1 United Kingdom 2 United States 11 Global 97

MedChemexpress LLC

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View Lastest Price from N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide manufacturers

Career Henan Chemical Co

Product: N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide 932986-18-0
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

932986-18-0, N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMideRelated Search:

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N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)butyraMide

N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide

Azoraminde

CS-1554

N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide

Butanamide, N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-

932986-18-0

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